PKRRATING FOR DUMMIES

3B). R526 with the loop amongst αJ and αI anchors the C-terminal part of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the leading chain carbonyl of R413. The tip from the activation section is stabilized by a hydrogen bond amongst Y454 and E480 from αfile. from th